Thumb Regions
I made a 1:1 scale cardboard iPad to start thinking about ways we can use it for artists and music in general. Some of the findings from playing with it on this scale are that interactivity on the device is really going to come down to what you do with one or both thumb regions in every orientation.
I traced my thumb boundaries in both orientations here and it will be interesting to see what developers do with these primary interactive regions, especially with gaming. I can imagine main controls on the left or right thumb, with contextual controls for your other hand and directional through accelerometer.
A lot of possibilities for sure.